THE BENEFITS OF BETA-HYDROXY BETA-METHYLBUTYRATE (OR HMB)

Beta-hydroxy-beta-methylbutyrate (or HMB) is often used to support muscle development in athletes8, but there is increasing evidence for its use in a clinical setting. So, how can it be used to support your patients?

Let’s start with the basics. Muscle is a dynamic tissue. It is continually in a cycle of synthesis and breakdown (or degradation). Building new tissue and breaking down old.1-2 To maintain muscle mass, the goal is to ensure that muscle breakdown is not happening faster than muscle synthesis.2

But as we age, this can become more difficult, as muscle loss naturally accelerates due to muscle breakdown increasing and muscle synthesis reducing.3 This problem is compounded by hospitalisation, mobility limitations or catabolic illness. For example, in patients who are frail, have cancer or COPD.3

We know that protein plays a significant role in muscle health. But where breakdown is happening faster than synthesis, consuming dietary protein may not be enough to restore the balance3.

This is where HMB comes in. It has three mechanisms of action♱ * 4-5,29. It supports muscle synthesis°*4, whilst uniquely protecting muscle from breakdown. It helps to stabilise muscle cell membranes, thereby improving the repair of damaged muscle cells.°, * , **4,29,31

HMB has been shown to double muscle protein synthesis.°*4,30 and reduce muscle protein breakdown by half.°*4,30

HMB also results in 10 times more muscle maintenance with the same protein intake.**31

So, how do we get it? HMB can be found in very small amounts in some foods, such as avocados and asparagus.28 But to get just 3g of HMB from diet alone, you would need to eat huge amounts of HMB-containing foods.28

Prescribing and recommending nutritional support with HMB is clinically proven to improve your patient’s muscle mass, strength, physical performance, and quality of life.8-9,15-16,†,#,‡

The benefits of oral nutritional supplements containing HMB are supported by evidence from over 18 clinical studies,9-27 demonstrating the capability of oral nutritional supplements containing HMB in supporting muscle health, strength, physical performance, and quality of life.8-9,15-16,†,#,‡

Prescribe or recommend nutritional support containing HMB for your patients today.

If you would like more information about Abbott products containing HMB, please click on the below

 
References:

1. Carbone JW & Pasiakos SM. Nutrients 2019;11(5):1136. 2. Tipton KD et al. Sports Med 2018;48(1):53-64. 3. Argilés JM et al. J Am Med Dir Assoc 2016;17(9):789-96. 4. Wilkinson DJ et al. J Physiol 2013;591:2911-23. 5. Deutz NE et al. Clin Nutr 2014;33(6):929-936. 6. Holeček m et al. J Cachexia Sarcopenia Muscle 2017;8(4):529-541. 7. Arazi H et al. Antioxidants (Basel) 2018;7(10):148. 8. Bear DE et al. Am J Clin Nutr 2019;109:1119-1132. 9. Peng LN et al. J Nutr Health Aging 2021;25(6):767-773. 10. Ashkenazi I et al. Geriatr Orhop Surg Rehabil DOI: 10.1177/21514593221102252 Published online 22nd May 2022. 11. Berton L et al. PLoS one 2015;10(11):e0141757. 12. Chavarro-Carvajal DA et al. Clin Nutr ESPEN 2022;48:291-297. 13. Cornejo-Pareja I et al. Nutrients 2021;13(12):4355. 14. Cramer JT et al. JAMDA; 2016;17(11):1044-1055. 15. De Luis DA et al. Eur Geriatr Med 2018;9(6):809-817. 16. De Luis DA et al. Nutr Hosp 2015;32(1):202-207. 17. Deutz NE et al. Clin Nutr 2016;35(1):18-26. 18. Deutz NE et al. Clin Nutr 2021;40(3):1388-1395. 19. Ekinci O et al. Nutr Clin Pract 2016;31(6):829-835. 20. Espina S et al. Nutrients 2021;13(11):3764. 21. Matheson EM et al. Clin Nutr 2021;40(3):844-849. 22. Malafarina V et al. Maturitas 2017;101:42-50. 23. Olveira G et al. Clin Nutr 2016;35(5):1015-1022. 24. Previtali P et al. Ann Surg Oncol 2020;27(6):2025-2032. 25. Ritch CR et al. J Urol 2019;201(3):470-477. 26. Standley RA et al. J Gerontol A Bio Sci Med Sci 2020;75(9):1744-1753. 27. Zana S et al. J Am Med Dir Assoc 2021;22(7):1358-1360. 28. Zhang Z et al. FASEB J 1994;8(4):A464, Abstr 2685. 29. Nissen SL & Abumrad NN. J Nutr Biochem 1997;8:300-311. 30. Engelen MPKJ & Deutz NEP. Curr Opin Clin Nutr Metab Care 2018;21(3):207-213. 31. Deutz NEP et al. Clin Nutr 2013;32:704-712.

† HMB (Beta-hydroxy-beta-methylbutyrate) is an active metabolite of leucine, among the constituent elements of proteins, naturally found in some foods, but in small quantities.
* Studied in healthy young males, over a period of 2.5 hours after receiving HMB supplementation.
°Compared to baseline at post-absorptive state.
**In a RCT including 19 healthy adults aged ≥60 years confined to bed rest for 10 days. CaHMB (3 g daily) prevented the decline in total LBM over bed rest (-0.17 ± 0.19 kg; p =0.23) in treated group versus control group (-2.05±0.66 kg; p =0.02)
# In a single arm open-label study of 148 patients aged 80±8.3 years with or at risk of malnutrition who consumed experimental product twice daily for 12 weeks as compared to baseline.
† An open label study of elderly (n = 35) patients with recent weight loss (>5% during previous 3 months) showed that 12 weeks supplementation of experimental product twice daily increased dietary intake, biochemical variables, and quality of life compared to baseline
‡In 62 community-dwelling pre-frail older people taking a specialised ONS vs nutritional counselling over 12 weeks.

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