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† HMB (Beta-hydroxy-beta-methylbutyrate) is an active metabolite of leucine, among the constituent elements of proteins, naturally found in some foods, but in small quantities.
* Studied in healthy young males, over a period of 2.5 hours after receiving HMB supplementation.
°Compared to baseline at post-absorptive state.
**In a RCT including 19 healthy adults aged ≥60 years confined to bed rest for 10 days. CaHMB (3 g daily) prevented the decline in total LBM over bed rest (-0.17 ± 0.19 kg; p =0.23) in treated group versus control group (-2.05±0.66 kg; p =0.02)
# In a single arm open-label study of 148 patients aged 80±8.3 years with or at risk of malnutrition who consumed experimental product twice daily for 12 weeks as compared to baseline.
† An open label study of elderly (n = 35) patients with recent weight loss (>5% during previous 3 months) showed that 12 weeks supplementation of experimental product twice daily increased dietary intake, biochemical variables, and quality of life compared to baseline
‡In 62 community-dwelling pre-frail older people taking a specialised ONS vs nutritional counselling over 12 weeks.
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