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THE BENEFITS OF BETA-HYDROXY BETA-METHYLBUTYRATE (OR HMB)

The benefits or oral nutritional supplements containing HMB are supported by evidence from over 18 clinical studies,9-27 Watch this short video to learn more about the benefits of HMB.

Prescribe or recommend nutritional support containing HMB for your patients today.

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Ensure Plus Advance is a 220 ml, ready-to-drink, oral nutritional supplement (ONS) formulated specifically for older adults who have, or are at risk of, malnutrition. It’s our most advanced ONS yet, with each bottle providing 330 kcal (1.5 kcal/ml), 20 g of protein, 13 μg of vitamin D (500 IU), 499 mg of calcium and 1.5g of CaHMB (calcium-β-hydroxy-β-methylbutyrate).

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Article: The Benefits of Beta-Hydroxy-Beta-Methylbutyrate (or HMB)

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HMB Article

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Article: The Benefits of Beta-Hydroxy-Beta-Methylbutyrate (or HMB)
Abstract

The benefits of oral nutritional supplements containing HMB are supported by evidence from over 18 clinical studies,9-27 read this short article to learn more about the benefits of HMB.

Content Reference
/content/an/hcpproconnect/uk/en/home/adult/resources/public/hmb-article

Footnotes:

† HMB (Beta-hydroxy-beta-methylbutyrate) is an active metabolite of leucine, among the constituent elements of proteins, naturally found in some foods, but in small quantities.
* Studied in healthy young males, over a period of 2.5 hours after receiving HMB supplementation.
°Compared to baseline at post-absorptive state.
**In a RCT including 19 healthy adults aged ≥60 years confined to bed rest for 10 days. CaHMB (3 g daily) prevented the decline in total LBM over bed rest (-0.17 ± 0.19 kg; p =0.23) in treated group versus control group (-2.05±0.66 kg; p =0.02)
# In a single arm open-label study of 148 patients aged 80±8.3 years with or at risk of malnutrition who consumed experimental product twice daily for 12 weeks as compared to baseline.
† An open label study of elderly (n = 35) patients with recent weight loss (>5% during previous 3 months) showed that 12 weeks supplementation of experimental product twice daily increased dietary intake, biochemical variables, and quality of life compared to baseline
‡In 62 community-dwelling pre-frail older people taking a specialised ONS vs nutritional counselling over 12 weeks.

References:

1. Carbone JW & Pasiakos SM. Nutrients 2019;11(5):1136. 2. Tipton KD et al. Sports Med 2018;48(1):53-64. 3. Argilés JM et al. J Am Med Dir Assoc 2016;17(9):789-96. 4. Wilkinson DJ et al. J Physiol 2013;591:2911-23. 5. Deutz NE et al. Clin Nutr 2014;33(6):929-936. 6. Holeček m et al. J Cachexia Sarcopenia Muscle 2017;8(4):529-541. 7. Arazi H et al. Antioxidants (Basel) 2018;7(10):148. 8. Bear DE et al. Am J Clin Nutr 2019;109:1119-1132. 9. Peng LN et al. J Nutr Health Aging 2021;25(6):767-773. 10. Ashkenazi I et al. Geriatr Orhop Surg Rehabil DOI: 10.1177/21514593221102252 Published online 22nd May 2022. 11. Berton L et al. PLoS one 2015;10(11):e0141757. 12. Chavarro-Carvajal DA et al. Clin Nutr ESPEN 2022;48:291-297. 13. Cornejo-Pareja I et al. Nutrients 2021;13(12):4355. 14. Cramer JT et al. JAMDA; 2016;17(11):1044-1055. 15. De Luis DA et al. Eur Geriatr Med 2018;9(6):809-817. 16. De Luis DA et al. Nutr Hosp 2015;32(1):202-207. 17. Deutz NE et al. Clin Nutr 2016;35(1):18-26. 18. Deutz NE et al. Clin Nutr 2021;40(3):1388-1395. 19. Ekinci O et al. Nutr Clin Pract 2016;31(6):829-835. 20. Espina S et al. Nutrients 2021;13(11):3764. 21. Matheson EM et al. Clin Nutr 2021;40(3):844-849. 22. Malafarina V et al. Maturitas 2017;101:42-50. 23. Olveira G et al. Clin Nutr 2016;35(5):1015-1022. 24. Previtali P et al. Ann Surg Oncol 2020;27(6):2025-2032. 25. Ritch CR et al. J Urol 2019;201(3):470-477. 26. Standley RA et al. J Gerontol A Bio Sci Med Sci 2020;75(9):1744-1753. 27. Zana S et al. J Am Med Dir Assoc 2021;22(7):1358-1360. 28. Zhang Z et al. FASEB J 1994;8(4):A464, Abstr 2685. 29. Nissen SL & Abumrad NN. J Nutr Biochem 1997;8:300-311. 30. Engelen MPKJ & Deutz NEP. Curr Opin Clin Nutr Metab Care 2018;21(3):207-213. 31. Deutz NEP et al. Clin Nutr 2013;32:704-712.

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ENSURE PLUS

1 x 220 ml

Flavor: Apple

UK-N/A-2400058 (V4) | July 2024

1,5 kcal / ml

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